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Triethylsilane → Ammonium Hydroxide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Triethylsilane | HCID 12052 | — |
| 反応物 | Methyl (4-nitro-1H-indol-3-yl)(oxo)acetate | HCID 10243717 | — |
| 溶媒 | Trifluoroacetic acid | HCID 6422 | — |
| 生成物 | Ammonium Hydroxide | HCID 14923 | — |
| 生成物 | methyl (4-nitro-2,3-dihydro-1H-indol-3-yl)-acetate | HCID 10243182 | — |
反応手順
To a stirred solution of methyl (4-nitro-1H-indol-3-yl)(oxo)acetate from Step A (563 mg, 2.27 mmol) in TFA (25 mL) at 0° C. was added triethylsilane (0.733 mL, 4.54 mmol). After 90 min, the reaction mixture was concentrated in vacuo and the residue was purified by silica gel chromatography, eluting with a gradient of CH2Cl2:MeOH:NH4OH—100:0:0 to 95:4.5:0.5, to give the title compound. MS: m/z=235 (M+1).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07947677B2 |
| 出典データセット | uspto-grants-2011_05 |
| ORD ID | ord-9b7b347391f74026b832f9656887d64b |
| 出典メモ | uspto-grants-2011_05 |