反应详情

To a stirred solution of methyl (4-nitro-1H-indol-3-yl)(oxo)acetate from Step A (563 mg, 2.27 mmol) in TFA (25 mL) at 0° C. was added triethylsilane (0.733 mL, 4.54 mmol). After 90 min, the reaction mixture was concentrated in vacuo and the residue was purified by silica gel chromatography, eluting with a gradient of CH2Cl2:MeOH:NH4OH—100:0:0 to 95:4.5:0.5, to give the title compound. MS: m/z=235 (M+1).

1. concentrationthe reaction mixture was concentrated in vacuo
2. customthe residue was purified by silica gel chromatography
3. washeluting with a gradient of CH2Cl2