Hydrochloric Acid → Lithium Chloride

HRID 55117ノート

反応式

HRID 55117 の反応式
C[O:2][C:3](=[O:19])[C@@H:4]1[CH2:8][CH2:7][C:6](=[O:9])[N:5]1[CH2:10][C:11]1[CH:16]=[CH:15][C:14]([C:17]#[N:18])=[CH:13][CH:12]=1.[Li+:20].[OH-].[ClH:22]>C1COCC1.O>[C:17]([C:14]1[CH:13]=[CH:12][C:11]([CH2:10][N:5]2[C:6](=[O:9])[CH2:7][CH2:8][C@H:4]2[C:3]([OH:19])=[O:2])=[CH:16][CH:15]=1)#[N:18].[Li+:20].[Cl-:22]

参加物

6

反応物 3

HCID 313Hydrochloric AcidHCID 3939Lithium HydroxideHCID 54410854N-(4-Cyanobenzyl)-L-pyroglutamic acid methyl ester

生成物 2

HCID 433294Lithium ChlorideHCID 22872280N-(4-Cyanobenzyl)-L-pyroglutamic acid

試薬・触媒・溶媒 1

HCID 21881883Oxolane--water (1/1)溶媒

実験手順

N-(4-Cyanobenzyl)-L-pyroglutamic acid methyl ester (0.875 g, 0.0034 mol) was dissolved in THF:H2O (3:1) (12 mL) and treated with LiOH (0.294 g, 0.007 mol) with stirring at ambient temperature. After stirring for 3 h, the solution was neutralized with 1N HCl, and concentrated to dryness to give the title compound and 2.1 eq of LiCl which was used without further purification.

後処理

  1. stirringAfter stirring for 3 h
  2. concentrationconcentrated to dryness

出典と根拠

ORDレコード
ord-f2485a4c07ac4dc0821a11680da6b71a
出典データセット
uspto-grants-1997_04
特許番号
US05624936

反応ノート

読み込み中…