Ethylamine → 3-(Ethylamino)-1,1,1-trifluoro-2-{[(1-phenyl-1H-indazol-4-yl)amino]methyl}-2-propanol

HRID 551428ノート

反応式

HRID 551428 の反応式
[C:1]1([N:7]2[C:15]3[CH:14]=[CH:13][CH:12]=[C:11]([NH:16][CH2:17][C:18]4([C:21]([F:24])([F:23])[F:22])[CH2:20][O:19]4)[C:10]=3[CH:9]=[N:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH2:25]([NH2:27])[CH3:26]>O1CCCC1>[CH2:25]([NH:27][CH2:20][C:18]([CH2:17][NH:16][C:11]1[CH:12]=[CH:13][CH:14]=[C:15]2[C:10]=1[CH:9]=[N:8][N:7]2[C:1]1[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1)([OH:19])[C:21]([F:24])([F:23])[F:22])[CH3:26]

参加物

4

反応物 2

HCID 6341EthylamineHCID 249380531-Phenyl-N-{[2-(trifluoromethyl)-2-oxiranyl]methyl}-1H-indazol-4-amine

生成物 1

HCID 593241573-(Ethylamino)-1,1,1-trifluoro-2-{[(1-phenyl-1H-indazol-4-yl)amino]methyl}-2-propanol

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

To a solution of 1-phenyl-N-{[2-(trifluoromethyl)-2-oxiranyl]methyl}-1H-indazol-4-amine (1.235 g, 3.7 mmol) in anhydrous tetrahydrofuran (5 ml) was added ethylamine (2M in tetrahydrofuran) (10 ml, 20 mmol). The reaction was stirred at room temperature for approximately 72 hours and then evaporated in vacuo to give the title compound.

後処理

  1. customevaporated in vacuo

出典と根拠

ORDレコード
ord-0b4b2774ad004c15abf2e7cbc7523362
出典データセット
uspto-grants-2011_05
特許番号
US07947727B2

反応ノート

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