Dimethylformamide → 1-(2-nitrophenyl)-1H-pyrrole-2-carbaldehyde

HRID 55144

反応式

HRID 55144 の反応式
[N+:1]([C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1[N:10]1[CH:14]=[CH:13][CH:12]=[CH:11]1)([O-:3])=[O:2].P(Cl)(Cl)(Cl)=O.[OH-].[Na+].CN(C)[CH:24]=[O:25]>>[N+:1]([C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1[N:10]1[CH:14]=[CH:13][CH:12]=[C:11]1[CH:24]=[O:25])([O-:3])=[O:2]

参加物

5

反応物 4

HCID 6228DimethylformamideHCID 14798Sodium HydroxideHCID 24813Phosphorus oxychlorideHCID 5206111-(2-Nitrophenyl)pyrrole

生成物 1

HCID 47153911-(2-nitrophenyl)-1H-pyrrole-2-carbaldehyde

反応条件

温度
90 °C

実験手順

To a solution of 3.76 g of 1-(2-nitrophenyl)pyrrole in 20 ml of N,N-dimethylformamide at 0° C. is added dropwise with stirring 3 ml of phosphorus oxychloride. Stirring is continued for 30 minutes and the reaction mixture is heated at 90° C. for 1 hour. After cooling to room temperature the mixture is treated with crushed ice and the pH adjusted to 12 with 2N sodium hydroxide. The resulting suspension is filtered, washed with water and dried to give 5.81 g of the desired product as a light yellow solid m.p. 119°-122° C.

後処理

  1. temperatureAfter cooling to room temperature the mixture
  2. additionis treated with crushed ice
  3. filtrationThe resulting suspension is filtered
  4. washwashed with water
  5. customdried

出典と根拠

ORDレコード
ord-f0b96011b8a949e4b7d887040eb61867
出典データセット
uspto-grants-1997_04
特許番号
US05624923

関連ノート

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