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Acetic Anhydride → acetic acid 1-acetyl-1H-indazol-4-ylmethyl ester
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Acetic Anhydride | HCID 7918 | — |
| 反応物 | Isoamyl Nitrite | HCID 8053 | — |
| 反応物 | 18-Crown-6 | HCID 28557 | — |
| 反応物 | Potassium Acetate | HCID 517044 | — |
| 反応物 | (3-Amino-2-methylphenyl)methanol | HCID 577175 | — |
| 溶媒 | Chloroform | HCID 6212 | — |
| 生成物 | acetic acid 1-acetyl-1H-indazol-4-ylmethyl ester | HCID 67151807 | — |
反応手順
3-Amino-2-methyl benzyl alcohol (0.82 g, 5.98 mmol), acetic anhydride (1.68 mL, 17.8 mmol), potassium acetate (1.75 g, 17.8 mol), isoamyl nitrite (1.82 mL, 13.7 mmol) and 18-crown-6 (79 mg, 0.3 mmol) in 25 mL CHCl3 were reacted as described in EP99/07620. The crude product was purified by flash chromatography with a gradient from 0-35% ethyl acetate in hexanes to yield acetic acid 1-acetyl-1H-indazol-4-ylmethyl ester.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07947728B1 |
| 出典データセット | uspto-grants-2011_05 |
| ORD ID | ord-b5aad79e57074a91ad948f17d033bbb6 |
| 出典メモ | uspto-grants-2011_05 |