反应详情

3-Amino-2-methyl benzyl alcohol (0.82 g, 5.98 mmol), acetic anhydride (1.68 mL, 17.8 mmol), potassium acetate (1.75 g, 17.8 mol), isoamyl nitrite (1.82 mL, 13.7 mmol) and 18-crown-6 (79 mg, 0.3 mmol) in 25 mL CHCl3 were reacted as described in EP99/07620. The crude product was purified by flash chromatography with a gradient from 0-35% ethyl acetate in hexanes to yield acetic acid 1-acetyl-1H-indazol-4-ylmethyl ester.

1. customThe crude product was purified by flash chromatography with a gradient from 0-35% ethyl acetate in hexanes