Butylate → 7-Methoxy-1-vinylnaphthalene

HRID 551776

反応式

HRID 551776 の反応式
CS(O[CH2:6][CH2:7][C:8]1[C:17]2[C:12](=[CH:13][CH:14]=[C:15]([O:18][CH3:19])[CH:16]=2)[CH:11]=[CH:10][CH:9]=1)(=O)=O.[K].CCSC(N(CC(C)C)CC(C)C)=O>O1CCCC1.O>[CH3:19][O:18][C:15]1[CH:16]=[C:17]2[C:12]([CH:11]=[CH:10][CH:9]=[C:8]2[CH:7]=[CH2:6])=[CH:13][CH:14]=1

参加物

6

反応物 3

HCID 16181ButylateHCID 5462222PotassiumHCID 190859902-(7-Methoxynaphthalen-1-yl)ethyl methanesulfonate

生成物 1

HCID 445416687-Methoxy-1-vinylnaphthalene

試薬・触媒・溶媒 2

HCID 962Water溶媒HCID 8028Tetrahydrofuran溶媒

実験手順

The compound obtained in Step A (21.4 mmol) is dissolved in 120 ml of tetrahydrofuran, and potassium tent-butylate (64.2 mmol) is added in small portions. After stirring for 30 minutes at ambient temperature, the reaction mixture is evaporated to dryness. The residue obtained is taken up in 150 ml of water and the aqueous phase is extracted twice with 60 ml of diethyl ether. The organic phase is washed with water, dried over magnesium sulphate, decolourised on vegetable carbon and evaporated. The residue obtained is purified on silica gel (eluant: petroleum ether) to yield the title product in the form of a yellow oil.

後処理

  1. customthe reaction mixture is evaporated to dryness
  2. customThe residue obtained
  3. extractionthe aqueous phase is extracted twice with 60 ml of diethyl ether
  4. washThe organic phase is washed with water
  5. dry with materialdried over magnesium sulphate
  6. customevaporated
  7. customThe residue obtained
  8. customis purified on silica gel (eluant: petroleum ether)

出典と根拠

ORDレコード
ord-c307d8c7baac4019b1c29cce6b41bdff
出典データセット
uspto-grants-2011_05
特許番号
US07947852B2

関連ノート

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