Potassium Acetate → N-[2-(7-Methoxy-1-naphthyl)-2-oxoethyl]acetamide

HRID 551779ノート

反応式

HRID 551779 の反応式
[OH:1][CH:2]([C:8]1[C:17]2[C:12](=[CH:13][CH:14]=[C:15]([O:18][CH3:19])[CH:16]=2)[CH:11]=[CH:10][CH:9]=1)[CH2:3][NH:4][C:5](=[O:7])[CH3:6].C([O-])(=O)C.[K+].[Cr](Cl)([O-])(=O)=O.[NH+]1C=CC=CC=1>ClCCl>[CH3:19][O:18][C:15]1[CH:16]=[C:17]2[C:12]([CH:11]=[CH:10][CH:9]=[C:8]2[C:2](=[O:1])[CH2:3][NH:4][C:5](=[O:7])[CH3:6])=[CH:13][CH:14]=1

参加物

5

反応物 3

HCID 517044Potassium AcetateHCID 44359309HCID 44359309、化合物HCID 178418287HCID 178418287、化合物

生成物 1

HCID 44541672N-[2-(7-Methoxy-1-naphthyl)-2-oxoethyl]acetamide

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒2 回

実験手順

The compound obtained in Step F (7.7 mmol) is dissolved in 200 ml of anhydrous dichloromethane. The resulting solution is added to a suspension of potassium acetate (0.23 g) and pyridinium chlorochromate (11.6 mmol) in 50 ml of dichloromethane. The reaction mixture is stirred at ambient temperature for 2 hours. It is then filtered over Celite. The filtrate is washed with water, decolourised on vegetable carbon and evaporated under reduced pressure. The residue obtained is triturated in diethyl ether, filtered off under suction and recrystallised from diisopropyl ether to yield the title product in the form of a white solid.

後処理

  1. filtrationIt is then filtered over Celite
  2. washThe filtrate is washed with water
  3. customevaporated under reduced pressure
  4. customThe residue obtained
  5. customis triturated in diethyl ether
  6. filtrationfiltered off under suction
  7. customrecrystallised from diisopropyl ether

出典と根拠

ORDレコード
ord-3d8f6233a57d498eb66559249da66e91
出典データセット
uspto-grants-2011_05
特許番号
US07947852B2

反応ノート

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