化工社化工社 化学情報印刷レポート · 研究参考用
Allyl chloroformate → 3beta-Carboallyloxyandrost-5-ene-7,17-dione
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Allyl chloroformate | HCID 18052 | — |
| 反応物 | 7-Keto-dehydroepiandrosterone | HCID 193313 | — |
| 溶媒 | Pyridine tetrahydrofuran | HCID 16069498 | — |
| 生成物 | 3beta-Carboallyloxyandrost-5-ene-7,17-dione | HCID 10237228 | 78% |
反応手順
Compound 43 was prepared from 7-oxo-DHEA (2) (1.0 mmol) and allylchloroformate (4.0 mmol) in tetrahydrofuran-pyridine mixture at 0-5° C. After stirring 6 hours only 30% conversion had occurred; from the mixture the product was isolated in 78% yield (based on 30% conversion) by column chromatography. M.p. 159-61° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07947846B2 |
| 出典データセット | uspto-grants-2011_05 |
| ORD ID | ord-6f73282656b34cddbebf95d4a3db0422 |
| 出典メモ | uspto-grants-2011_05 |