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HRID551840

反应详情

EQUATION

反应方程式

HRID 551840 的结构方程式

REACTANTS

反应物

2
结构：C=CCOC(=O)Cl
HCID18052

Allyl chloroformate

C4H5ClO2

结构：C[C@]12CC[C@H](O)CC1=CC(=O)[C@@H]1[C@@H]2CC[C@]2(C)C(=O)CC[C@@H]12
HCID193313

7-Ketodehydroepiandrosterone

C19H26O3

PRODUCTS

生成物

1
结构：C=CCOC(=O)[C@H]1CC[C@@]2(C)C(=CC(=O)[C@@H]3[C@@H]2CC[C@]2(C)C(=O)CC[C@@H]32)C1
HCID10237228

未命名化合物

收率 78%

AUXILIARIES

试剂、催化剂与溶剂

1
结构：C1CCOC1.c1ccncc1
溶剂HCID16069498

未命名化合物

PROCEDURE

实验过程

Compound 43 was prepared from 7-oxo-DHEA (2) (1.0 mmol) and allylchloroformate (4.0 mmol) in tetrahydrofuran-pyridine mixture at 0-5° C. After stirring 6 hours only 30% conversion had occurred; from the mixture the product was isolated in 78% yield (based on 30% conversion) by column chromatography. M.p. 159-61° C.

WORKUP

后处理

  1. customfrom the mixture the product was isolated in 78% yield (based on 30% conversion) by column chromatography