Sodium Hydroxide → 4-(6-Bromo-imidazo[1,2-a]pyrazin-8-ylamino)-benzoic Acid
反応式
C([O:3][C:4](=[O:22])[C:5]1[CH:10]=[CH:9][C:8]([NH:11][C:12]2[C:13]3[N:14]([CH:19]=[CH:20][N:21]=3)[CH:15]=[C:16]([Br:18])[N:17]=2)=[CH:7][CH:6]=1)C.[OH-].[Na+]>C(O)C>[Br:18][C:16]1[N:17]=[C:12]([NH:11][C:8]2[CH:7]=[CH:6][C:5]([C:4]([OH:22])=[O:3])=[CH:10][CH:9]=2)[C:13]2[N:14]([CH:19]=[CH:20][N:21]=2)[CH:15]=1参加物
4
実験手順
4-(6-Bromo-imidazo[1,2-a]pyrazin-8-ylamino)-benzoic acid ethyl ester (10.0 g; 27.7 mmol) is dissolved in 200 mL ethanol (200 proof) and 100 mL 1 N NaOH is added. The reaction is refluxed for 2 hours and then cooled to rt. The resulting solid is filtered and collected, then slurried up in 0.1 N HCl (75 mL) and extracted with CH2Cl2 (2×75 mL). The pooled CH2Cl2 layers is washed with brine, then dried over anhydrous sodium sulfate and concentrated in vacuo to provide 4-(6-bromo-imidazo[1,2-a]pyrazin-8-ylamino)-benzoic acid as a white solid (8 g).