Trifluoroacetic acid → 4-[2-(Trifluoromethyl)phenoxy]piperidine

HRID 552133

反応式

HRID 552133 の反応式
C(OC([N:8]1[CH2:13][CH2:12][CH:11]([O:14][C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=2[C:21]([F:24])([F:23])[F:22])[CH2:10][CH2:9]1)=O)(C)(C)C.FC(F)(F)C(O)=O>ClCCl>[F:24][C:21]([F:22])([F:23])[C:16]1[CH:17]=[CH:18][CH:19]=[CH:20][C:15]=1[O:14][CH:11]1[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]1

参加物

4

反応物 2

HCID 6422Trifluoroacetic acidHCID 46941590Tert-butyl 4-(2-(trifluoromethyl)phenoxy)piperidine-1-carboxylate

生成物 1

HCID 50187904-[2-(Trifluoromethyl)phenoxy]piperidine

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

To a stirred solution of 4-(2-trifluoromethylphenoxy)piperidine-1-carboxylic acid tert-butyl ester (1.413 g, 4.000 mmol) in dichloromethane (40.0 mL) was added trifluoroacetic acid (6.0 mL, 80.00 mmol). The resulting mixture was stirred at ambient temperature for 24 hours and then quenched with a saturated aqueous solution of Na2CO3 (10.0 mL). The organic phase was washed with water (20.0 mL), brine (20.0 mL), dried over MgSO4 and then concentrated in vacuo. The obtained crude product was used without further purification.

後処理

  1. customquenched with a saturated aqueous solution of Na2CO3 (10.0 mL)
  2. washThe organic phase was washed with water (20.0 mL), brine (20.0 mL)
  3. dry with materialdried over MgSO4
  4. concentrationconcentrated in vacuo
  5. customThe obtained crude product
  6. customwas used without further purification

出典と根拠

ORDレコード
ord-cb2b8ca704fd4177be7ad128def6c2cf
出典データセット
uspto-grants-2011_05
特許番号
US07951805B2

関連ノート

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