Thionyl Chloride → 3-Fluoro-2-methylbenzoyl chloride
反応式
[F:1][C:2]1[C:3]([CH3:11])=[C:4]([CH:8]=[CH:9][CH:10]=1)[C:5](O)=[O:6].S(Cl)([Cl:14])=O>>[F:1][C:2]1[C:3]([CH3:11])=[C:4]([CH:8]=[CH:9][CH:10]=1)[C:5]([Cl:14])=[O:6]参加物
3
実験手順
A solution of 2.87 g of 3-fluoro-2-methylbenzoic acid in 25 ml of thionyl chloride is refluxed for 1.75 hour and the excess thionyl chloride removed under vacuum. To the residue is added toluene (several times) and the toluene removed under vacuum after each addition to give 3-fluoro-2-methylbenzoyl chloride.
後処理
- customthe excess thionyl chloride removed under vacuum
- additionTo the residue is added toluene (several times)
- customthe toluene removed under vacuum
- additionafter each addition
出典と根拠
- ORDレコード
- ord-68580e8b0b3e49b7b5833ece3c1c71da
- 出典データセット
- uspto-grants-1997_04
- 特許番号
- US05624923
反応ノート
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