Water → HCID 67166148、化合物

HRID 552333ノート

反応式

HRID 552333 の反応式
[C:1]([N:4]1[CH2:21][CH2:20][C:7]2([NH:11][C:10](=[O:12])[C@H:9]([CH2:13][C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=3)[NH:8]2)[CH2:6][CH2:5]1)(=[O:3])[CH3:2].O.C[Si]([Cl:27])(C)C>CC(CC)=O>[ClH:27].[C:1]([N:4]1[CH2:5][CH2:6][C:7]2([NH:11][C:10](=[O:12])[C@H:9]([CH2:13][C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=3)[NH:8]2)[CH2:20][CH2:21]1)(=[O:3])[CH3:2]

参加物

5

反応物 3

HCID 962WaterHCID 6397ChlorotrimethylsilaneHCID 67166149HCID 67166149、化合物

生成物 1

HCID 67166148HCID 67166148、化合物

試薬・触媒・溶媒 1

HCID 6569Methyl Ethyl Ketone溶媒

実験手順

8-Acetyl-3-(S)-benzyl-1,4,8-triazaspiro[4,5]decan-2-one (300 mg, 1.0 mmol) was dissolved in ethyl methyl ketone (2 ml), treated with water (21 μL) and TMSCl (290 μL) and stirred overnight. The solid precipitated in this process was filtered off, washed with ether and dried in vacuo. The product 8-acetyl-3-(S)-benzyl-1,4,8-triazaspiro[4,5]decan-2-one hydrochloride was obtained in a yield of 330 mg (96%).

後処理

  1. customThe solid precipitated in this process
  2. filtrationwas filtered off
  3. washwashed with ether
  4. customdried in vacuo

出典と根拠

ORDレコード
ord-89347e820dee4ebb925a917e97995dbd
出典データセット
uspto-grants-2011_05
特許番号
US07951815B2

反応ノート

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