Hydrogen Bromide → 4-Bromo-6-methylpyridine-2-carboxylic acid

HRID 552483ノート

反応式

HRID 552483 の反応式
[CH3:1][C:2]1[N:7]=[C:6]([C:8]([OH:10])=[O:9])[CH:5]=[C:4]([N+]([O-])=O)[CH:3]=1.[BrH:14]>>[Br:14][C:4]1[CH:3]=[C:2]([CH3:1])[N:7]=[C:6]([C:8]([OH:10])=[O:9])[CH:5]=1

参加物

3

反応物 2

HCID 260Hydrogen BromideHCID 112753916-methyl-4-nitropicolinic acid

生成物 1

HCID 534852954-Bromo-6-methylpyridine-2-carboxylic acid

実験手順

A solution of 3.6 g (19.6 mmol) of 6-Methyl-4-nitro-pyridine-2-carboxylic acid in 40 ml of 48% hydrobromic acid was heated at 100° C. overnight and then allowed to cool to room temperature. The solution was then evaporated to dryness in vaccuo. The crude material (10.5 g) containing inorganic salts was directly used in the next step.

後処理

  1. customThe solution was then evaporated to dryness in vaccuo
  2. additionThe crude material (10.5 g) containing inorganic salts

出典と根拠

ORDレコード
ord-7534d19fc07f4379a371d23045f25060
出典データセット
uspto-grants-2011_05
特許番号
US07951824B2

反応ノート

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