Methyl iodide → 3-{3-[3-(4-Acetyl-3-methoxy-2-propylphenoxy)-propoxy]-2-pyridyl}-propionic acid methyl ester
反応式
[CH3:1][O:2][C:3](=[O:30])[CH2:4][CH2:5][C:6]1[C:11]([O:12][CH2:13][CH2:14][CH2:15][O:16][C:17]2[CH:22]=[CH:21][C:20]([C:23](=[O:25])[CH3:24])=[C:19]([OH:26])[C:18]=2[CH2:27][CH2:28][CH3:29])=[CH:10][CH:9]=[CH:8][N:7]=1.[C:31](=O)([O-])[O-].[Cs+].[Cs+].IC>>[CH3:1][O:2][C:3](=[O:30])[CH2:4][CH2:5][C:6]1[C:11]([O:12][CH2:13][CH2:14][CH2:15][O:16][C:17]2[CH:22]=[CH:21][C:20]([C:23](=[O:25])[CH3:24])=[C:19]([O:26][CH3:31])[C:18]=2[CH2:27][CH2:28][CH3:29])=[CH:10][CH:9]=[CH:8][N:7]=1参加物
4
実験手順
Under the conditions of example 2 A, 600 mg of 3-{3-[3-(4-acetyl-3-hydroxy-2-propylphenoxy)-propoxy]-2-pyridyl}-propionic acid methyl ester in the presence of 940 mg of cesium carbonate instead of potassium carbonate is reacted with 205 mg of iodomethane, worked up, and the crude product is chromatographed on silica gel with hexane/0-10% ethyl acetate. 570 mg of 3-{3-[3-(4-acetyl-3-methoxy-2-propylphenoxy)-propoxy]-2-pyridyl}-propionic acid methyl ester is obtained as oil.
後処理
- customthe crude product is chromatographed on silica gel with hexane/0-10% ethyl acetate
出典と根拠
- ORDレコード
- ord-6418b49c36394e6e902886b5499d3266
- 出典データセット
- uspto-grants-1997_04
- 特許番号
- US05624943
反応ノート
読み込み中…