N-Iodosuccinimide → 5-Iodo-4-phenethyl-7H-pyrrolo[2,3-d]pyrimidine
反応式
[CH2:1]([C:9]1[C:10]2[CH:17]=[CH:16][NH:15][C:11]=2[N:12]=[CH:13][N:14]=1)[CH2:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1.[I:18]N1C(=O)CCC1=O>C(C#N)(C)=O>[I:18][C:17]1[C:10]2[C:9]([CH2:1][CH2:2][C:3]3[CH:4]=[CH:5][CH:6]=[CH:7][CH:8]=3)=[N:14][CH:13]=[N:12][C:11]=2[NH:15][CH:16]=1参加物
4
実験手順
To a solution of 4-phenethyl-7H-pyrrolo[2,3-d]pyrimidine (3.15 g, 14.1 mmol) in AcCN was added N-iodosuccinimide and the mixture was stirred at r.t. for 12 hr. The precipitate was collected and recrystallized from MeOH to give the title compound (4.06 g, 83%).
後処理
- customThe precipitate was collected
- customrecrystallized from MeOH
出典と根拠
- ORDレコード
- ord-e42ee6c2035c44cebf97eba7cb5a59ff
- 出典データセット
- uspto-grants-2011_05
- 特許番号
- US07951810B2
反応ノート
読み込み中…