3-{3-Hydroxy-6-[2-(4-methoxycarbonylmethylphenyl)-ethinyl]-2-pyridyl}-propionic acid methyl ester → 3-{3-Hydroxy-6-[2-(4-methoxycarbonylmethylphenyl)-ethyl]-2-pyridyl}-propionic acid-methyl ester

HRID 55300ノート

反応式

HRID 55300 の反応式
[CH3:1][O:2][C:3](=[O:26])[CH2:4][CH2:5][C:6]1[C:11]([OH:12])=[CH:10][CH:9]=[C:8]([C:13]#[C:14][C:15]2[CH:20]=[CH:19][C:18]([CH2:21][C:22]([O:24][CH3:25])=[O:23])=[CH:17][CH:16]=2)[N:7]=1>CO.[Pd]>[CH3:1][O:2][C:3](=[O:26])[CH2:4][CH2:5][C:6]1[C:11]([OH:12])=[CH:10][CH:9]=[C:8]([CH2:13][CH2:14][C:15]2[CH:16]=[CH:17][C:18]([CH2:21][C:22]([O:24][CH3:25])=[O:23])=[CH:19][CH:20]=2)[N:7]=1

参加物

4

反応物 1

HCID 677037393-{3-Hydroxy-6-[2-(4-methoxycarbonylmethylphenyl)-ethinyl]-2-pyridyl}-propionic acid methyl ester

生成物 1

HCID 537837203-{3-Hydroxy-6-[2-(4-methoxycarbonylmethylphenyl)-ethyl]-2-pyridyl}-propionic acid-methyl ester収率 52.6%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 887Methanol溶媒

実験手順

Under the conditions of example 14 A, a solution of 500 mg of 3-{3-hydroxy-6-[2-(4-methoxycarbonylmethylphenyl)-ethinyl]-2-pyridyl}-propionic acid-methyl ester in 5 ml of methanol is hydrogenated in the presence of 50 mg of 10% palladium catalyston activated carbon and worked up. The crude product is chromatographed on silica gel with hexane/0-30% ethyl acetate. 266 mg of 3-{3-hydroxy-6-[2-(4-methoxycarbonylmethylphenyl)-ethyl]-2-pyridyl}-propionic acid-methyl ester of melting point 90°-91° is obtained.

後処理

  1. customThe crude product is chromatographed on silica gel with hexane/0-30% ethyl acetate

出典と根拠

ORDレコード
ord-1b530ebb08e4421a9e6d9fc4a06a0b49
出典データセット
uspto-grants-1997_04
特許番号
US05624943

反応ノート

読み込み中…