反応式
[CH:1]1[CH:2]=[CH:3][C:4]([CH:7]([S+:14]([O-:19])[CH2:15][C:16]([NH2:18])=[O:17])[C:8]2[CH:9]=[CH:10][CH:11]=[CH:12][CH:13]=2)=[CH:5][CH:6]=1.C1(C(C2C=CC=CC=2)S(CC(O)=O)=O)C=CC=CC=1.CC(N)C1C=CC=CC=1>C(O)C>[CH:11]1[CH:10]=[CH:9][C:8]([CH:7]([S@@:14]([CH2:15][C:16]([NH2:18])=[O:17])=[O:19])[C:4]2[CH:5]=[CH:6][CH:1]=[CH:2][CH:3]=2)=[CH:13][CH:12]=1参加物
5
実験手順
U.S. Pat. No. 4,927,855 describes the preparation of the levorotatory enantiomer of modafinil by chiral resolution of the 2-[(diphenylmethyl)sulfinyl]acetic acid with α-methylbenzyl amine. After recovery and amidation of the enantiomerically pure acid, (−) modafinil was obtained as white crystals by crystallization from ethanol.
出典と根拠
- ORDレコード
- ord-58141b0965b24d8e90d911acee886957
- 出典データセット
- uspto-grants-2011_11
- 特許番号
- US08048222B2
関連ノート
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