2-(N-tert-butylsulfamoyl)-N-phenylacetamide → N-phenyl-2-sulfamoylacetamide

HRID 553467ノート

反応式

HRID 553467 の反応式
C([NH:5][S:6]([CH2:9][C:10]([NH:12][C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)=[O:11])(=[O:8])=[O:7])(C)(C)C>C(O)(C(F)(F)F)=O>[S:6]([CH2:9][C:10]([NH:12][C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)=[O:11])(=[O:7])(=[O:8])[NH2:5]

参加物

3

反応物 1

HCID 579245132-(N-tert-butylsulfamoyl)-N-phenylacetamide

生成物 1

HCID 21435949N-phenyl-2-sulfamoylacetamide収率 96.4%

試薬・触媒・溶媒 1

HCID 6422Trifluoroacetic acid溶媒

実験手順

The solution of compound 2-(N-tert-butylsulfamoyl)-N-phenylacetamide (2.5 g, 9.2 mmol.) in 40 mL of TFA was stirred at room temperature overnight. TLC analysis showed the reaction complete. Excess TFA was removed in vacuo. The value of pH was adjusted to 7-8 with NaHCO3. The mixture was extracted with EtOAc (30 mL×3). The combined organic layer was over Na2SO4, concentrated to afford compound 2-(sulfamoyl)-N-phenylacetamide (1.9 g, 96%), which was used directly without purification.

後処理

  1. customthe reaction complete
  2. customExcess TFA was removed in vacuo
  3. extractionThe mixture was extracted with EtOAc (30 mL×3)
  4. concentrationconcentrated

出典と根拠

ORDレコード
ord-f61b1478c836490cbcaeb3150c00e29a
出典データセット
uspto-grants-2011_11
特許番号
US08048862B2

反応ノート

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