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Sodium Carbonate → 2-(2-sulfamoylphenoxy)-N-methylacetamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Sodium Carbonate | HCID 10340 | — |
| 反応物 | Cesium carbonate | HCID 10796 | — |
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | Sodium Bicarbonate | HCID 516892 | — |
| 反応物 | Potassium Bicarbonate | HCID 516893 | — |
| 反応物 | 2-Hydroxybenzene-1-sulfonamide | HCID 637546 | — |
| 反応物 | 2-Bromo-N-methylacetamide | HCID 15490745 | — |
| 生成物 | 2-(2-sulfamoylphenoxy)-N-methylacetamide | HCID 57924329 | — |
反応手順
2-(2-Sulfamoylphenoxy)-N-methylacetamide can be prepared according to the method of Scheme XXXIX. Bromoacetyl bromide can be reacted methylamine hydrochloride in the presence of a base, such as sodium hydroxide to afford 2-bromo-N-methylacetamide. The phenoxy group of 1-(hydroxy)-2-sulfamoylbenzene can be alkylated with 2-bromo-N-methylacetamide in the presence of a base, such as cesium carbonate, sodium carbonate, potassium carbonate, sodium bicarbonate, potassium bicarbonate, and the like, to afford 2-(2-sulfamoylphenoxy)-N-methylacetamide.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08048862B2 |
| 出典データセット | uspto-grants-2011_11 |
| ORD ID | ord-03d8eda5f97b4236b8da1b60fe3c20b6 |
| 出典メモ | uspto-grants-2011_11 |