反应详情

2-(2-Sulfamoylphenoxy)-N-methylacetamide can be prepared according to the method of Scheme XXXIX. Bromoacetyl bromide can be reacted methylamine hydrochloride in the presence of a base, such as sodium hydroxide to afford 2-bromo-N-methylacetamide. The phenoxy group of 1-(hydroxy)-2-sulfamoylbenzene can be alkylated with 2-bromo-N-methylacetamide in the presence of a base, such as cesium carbonate, sodium carbonate, potassium carbonate, sodium bicarbonate, potassium bicarbonate, and the like, to afford 2-(2-sulfamoylphenoxy)-N-methylacetamide.