Ethanol → Ethyl 3-bromo-4-methoxyphenylacetate

HRID 553659ノート

反応式

HRID 553659 の反応式
[Br:1][C:2]1[CH:3]=[C:4]([CH2:10][C:11]([OH:13])=[O:12])[CH:5]=[CH:6][C:7]=1[O:8][CH3:9].S(Cl)(Cl)=O.C([O-])(O)=O.[Na+].[CH2:23](O)[CH3:24]>>[CH2:23]([O:12][C:11](=[O:13])[CH2:10][C:4]1[CH:5]=[CH:6][C:7]([O:8][CH3:9])=[C:2]([Br:1])[CH:3]=1)[CH3:24]

参加物

5

反応物 4

HCID 702EthanolHCID 24386Thionyl ChlorideHCID 1366153-Bromo-4-methoxyphenylacetic acidHCID 516892Sodium Bicarbonate

生成物 1

HCID 57419861Ethyl 3-bromo-4-methoxyphenylacetate

実験手順

To 3-bromo-4-methoxyphenylacetic acid (24 g, 97.9 mmol) in ethanol (240 mL) was added thionyl chloride (7.8 mL, 107.7 mmol), and the reaction was stirred at room temperature for 1 hour. Once no starting material was seen by analytical LCMS, the mixture was basified with saturated aqueous NaHCO3 and extracted with dichloromethane. The combined organic layers were dried over MgSO4, filtered, and concentrated to give the desired product.

後処理

  1. extractionextracted with dichloromethane
  2. dry with materialThe combined organic layers were dried over MgSO4
  3. filtrationfiltered
  4. concentrationconcentrated

出典と根拠

ORDレコード
ord-edc7daea5a054297af3eeba2d3d0a5f3
出典データセット
uspto-grants-2011_11
特許番号
US08048902B2

反応ノート

読み込み中…