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Hydrochloric Acid → (E)-4-{(4S*,9aR*)-7-[3-methoxy-4-(4-methyl-1H-imidazol-1-yl)benzylidene]-6-oxooctahydroquinolizin-4-yl}benzoic acid

HRID 553901
ノート
印刷プレビュー

反応式

HRID 553901 の反応式
[OH-].[Na+].[CH3:3][O:4][C:5]1[CH:6]=[C:7]([CH:30]=[CH:31][C:32]=1[N:33]1[CH:37]=[C:36]([CH3:38])[N:35]=[CH:34]1)/[CH:8]=[C:9]1/[C:10](=[O:29])[N:11]2[C@@H:16]([CH2:17][CH2:18]/1)[CH2:15][CH2:14][CH2:13][C@H:12]2[C:19]1[CH:28]=[CH:27][C:22]([C:23]([O:25]C)=[O:24])=[CH:21][CH:20]=1.Cl>CO>[CH3:3][O:4][C:5]1[CH:6]=[C:7]([CH:30]=[CH:31][C:32]=1[N:33]1[CH:37]=[C:36]([CH3:38])[N:35]=[CH:34]1)/[CH:8]=[C:9]1/[C:10](=[O:29])[N:11]2[C@@H:16]([CH2:17][CH2:18]/1)[CH2:15][CH2:14][CH2:13][C@H:12]2[C:19]1[CH:28]=[CH:27][C:22]([C:23]([OH:25])=[O:24])=[CH:21][CH:20]=1
参加物実験手順後処理出典と根拠反応ノート

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 24779885methyl (E)-4-{(4S*,9aR*)-7-[3-methoxy-4-(4-methyl-1H-imidazol-1-yl)benzylidene]-6-oxooctahydroquinolizin-4-yl}benzoate

生成物 1

HCID 24780024(E)-4-{(4S*,9aR*)-7-[3-methoxy-4-(4-methyl-1H-imidazol-1-yl)benzylidene]-6-oxooctahydroquinolizin-4-yl}benzoic acid収率 99.1%

試薬・触媒・溶媒 1

HCID 887
Methanol
溶媒

実験手順

A 2 N sodium hydroxide solution (1 mL) was added to a solution of methyl (E)-4-{(4S*,9aR*)-7-[3-methoxy-4-(4-methyl-1H-imidazol-1-yl)benzylidene]-6-oxooctahydroquinolizin-4-yl}benzoate (80 mg) in methanol (2 mL), and the reaction solution was stirred at room temperature for 18 hours. 2 N hydrochloric acid (1 mL) was added to the reaction solution, and the solution was concentrated under reduced pressure. The resulting residue was purified by silica gel column chromatography (elution solvent: chloroform:methanol=5:1) to obtain 77 mg of the title compound. The property values of the compound are as follows.

後処理

  1. concentrationthe solution was concentrated under reduced pressure
  2. customThe resulting residue was purified by silica gel column chromatography (elution solvent: chloroform:methanol=5:1)

出典と根拠

ORDレコード
ord-f9b18b2bec9d46dea9135d61af476da3
出典データセット
uspto-grants-2011_11
DOI
10.6084/m9.figshare.5104873.v1
特許番号
US08048878B2

反応ノート

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