Sodium hydride → 4-Methyl-5-phenyl-1-(3-thienylsulfonyl)-1H-pyrrole-3-carbaldehyde

反応式

[CH3:1][C:2]1[C:3]([CH:13]=[O:14])=[CH:4][NH:5][C:6]=1[C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1.[H-].[Na+].C1OCCOCCOCCOCCOC1.[S:32]1[CH:36]=[CH:35][C:34]([S:37](Cl)(=[O:39])=[O:38])=[CH:33]1>>[CH3:1][C:2]1[C:3]([CH:13]=[O:14])=[CH:4][N:5]([S:37]([C:34]2[CH:35]=[CH:36][S:32][CH:33]=2)(=[O:39])=[O:38])[C:6]=1[C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1

参加物

反応物 4

HCID 24758Sodium hydride

HCID 3633615-Crown-5

HCID 2776378Thiophene-3-sulfonyl Chloride

HCID 713628124-Methyl-5-phenyl-1H-pyrrole-3-carbaldehyde

生成物 1

HCID 862327164-Methyl-5-phenyl-1-(3-thienylsulfonyl)-1H-pyrrole-3-carbaldehyde収率 88%

実験手順

Using 4-methyl-5-phenyl-1H-pyrrole-3-carbaldehyde (185 mg), sodium hydride (60% in oil, 60 mg), 15-crown-5 (0.30 mL) and (3-thienyl)sulfonyl chloride (237 mg), a procedure as in Reference Example 219 was performed to give the title compound as a solid (yield 290 mg, 88%).

出典と根拠

ORDレコード: ord-882b43de2c2c45cb874b041085cf2c2c
出典データセット: uspto-grants-2011_11
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US08048909B2

反応ノート

読み込み中…