Methanamine, hydrochloride (1:1) → N-Methyl-1-{4-methyl-1-[(4-methylphenyl)sulfonyl]-5-phenyl-1H-pyrrol-3-yl}methanamine hydrochloride

反応式

[CH3:1][C:2]1[C:3]([CH:23]=O)=[CH:4][N:5]([S:13]([C:16]2[CH:21]=[CH:20][C:19]([CH3:22])=[CH:18][CH:17]=2)(=[O:15])=[O:14])[C:6]=1[C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1.[Cl-:25].C[NH3+].[C:28]([BH3-])#[N:29].[Na+]>>[ClH:25].[CH3:28][NH:29][CH2:23][C:3]1[C:2]([CH3:1])=[C:6]([C:7]2[CH:8]=[CH:9][CH:10]=[CH:11][CH:12]=2)[N:5]([S:13]([C:16]2[CH:21]=[CH:20][C:19]([CH3:22])=[CH:18][CH:17]=2)(=[O:14])=[O:15])[CH:4]=1

参加物

反応物 3

HCID 11637Methanamine, hydrochloride (1:1)

HCID 5003444Sodium cyanoborohydride

HCID 866207414-Methyl-1-[(4-methylphenyl)sulfonyl]-5-phenyl-1H-pyrrole-3-carbaldehyde

生成物 1

HCID 66924933N-Methyl-1-{4-methyl-1-[(4-methylphenyl)sulfonyl]-5-phenyl-1H-pyrrol-3-yl}methanamine hydrochloride収率 50.1%

実験手順

Using 4-methyl-1-[(4-methylphenyl)sulfonyl]-5-phenyl-1H-pyrrole-3-carbaldehyde (310 mg), methylammonium chloride (617 mg) and sodium cyanoborohydride (172 mg), a procedure as in Example 4 was performed to give the title compound as colorless crystals (yield 179 mg, 50%).

出典と根拠

ORDレコード: ord-b4e98dbc1dd046cbab5250eb05e3411a
出典データセット: uspto-grants-2011_11
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US08048909B2

反応ノート

読み込み中…