Sodium hydride → 1-[1-(Butylsulfonyl)-5-phenyl-1H-pyrrol-3-yl]-N-methylmethanamine

HRID 554404

反応式

HRID 554404 の反応式
C[N:2]([CH2:10][C:11]1[CH:15]=[C:14]([C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)[NH:13][CH:12]=1)[C:3](=O)OC(C)(C)C.[H-].[Na+].[CH2:24]([S:28](Cl)(=[O:30])=[O:29])[CH2:25][CH2:26][CH3:27]>>[CH2:24]([S:28]([N:13]1[C:14]([C:16]2[CH:17]=[CH:18][CH:19]=[CH:20][CH:21]=2)=[CH:15][C:11]([CH2:10][NH:2][CH3:3])=[CH:12]1)(=[O:30])=[O:29])[CH2:25][CH2:26][CH3:27]

参加物

4

反応物 3

HCID 24758Sodium hydrideHCID 754301-Butanesulfonyl chlorideHCID 57522146Tert-butyl methyl[(5-phenyl-1H-pyrrol-3-YL)methyl]carbamate

生成物 1

HCID 669249311-[1-(Butylsulfonyl)-5-phenyl-1H-pyrrol-3-yl]-N-methylmethanamine収率 24%

実験手順

Using tert-butyl methyl[(5-phenyl-1H-pyrrol-3-yl)methyl]carbamate (70 mg), sodium hydride (60% in oil, 98 mg) and butane-1-sulfonyl chloride (230 mg), a procedure as in Example 38 was performed to give the title compound as pale-purplish red crystals (yield 18 mg, 21%).

出典と根拠

ORDレコード
ord-eea15db9a3b84e109d374ed1e2ba4958
出典データセット
uspto-grants-2011_11
特許番号
US08048909B2

関連ノート

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