Sodium hydride → 1-{1-[(3-Methoxyphenyl)sulfonyl]-5-phenyl-1H-pyrrol-3-yl}-N-methylmethanamine hydrochloride

反応式

C[N:2]([CH2:10][C:11]1[CH:15]=[C:14]([C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)[NH:13][CH:12]=1)[C:3](=O)OC(C)(C)C.[H-].[Na+].[CH3:24][O:25][C:26]1[CH:27]=[C:28]([S:32]([Cl:35])(=[O:34])=[O:33])[CH:29]=[CH:30][CH:31]=1>>[ClH:35].[CH3:24][O:25][C:26]1[CH:27]=[C:28]([S:32]([N:13]2[C:14]([C:16]3[CH:17]=[CH:18][CH:19]=[CH:20][CH:21]=3)=[CH:15][C:11]([CH2:10][NH:2][CH3:3])=[CH:12]2)(=[O:34])=[O:33])[CH:29]=[CH:30][CH:31]=1

参加物

反応物 3

HCID 24758Sodium hydride

HCID 27375043-Methoxybenzenesulfonyl chloride

HCID 57522146Tert-butyl methyl[(5-phenyl-1H-pyrrol-3-YL)methyl]carbamate

生成物 1

HCID 575221431-{1-[(3-Methoxyphenyl)sulfonyl]-5-phenyl-1H-pyrrol-3-yl}-N-methylmethanamine hydrochloride収率 68%

実験手順

Using tert-butyl methyl[(5-phenyl-1H-pyrrol-3-yl)methyl]carbamate (200 mg), sodium hydride (60% in oil, 140 mg) and 3-methoxybenzenesulfonyl chloride (433 mg), a procedure as in Example 36 was performed to give the title compound as pale-purple crystals (yield 186 mg, 68%).

出典と根拠

ORDレコード: ord-f966d1dcaa354d3d9c3bcb083e1943db
出典データセット: uspto-grants-2011_11
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US08048909B2

反応ノート

読み込み中…