Sodium borohydride → HCID 66924845、化合物

反応式

[Cl:1][C:2]1[C:3]([CH:23]=O)=[C:4]([CH3:22])[N:5]([S:13]([C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)(=[O:15])=[O:14])[C:6]=1[C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1.CO.[CH3:27][NH2:28].[BH4-].[Na+]>>[ClH:1].[Cl:1][C:2]1[C:3]([CH2:23][NH:28][CH3:27])=[C:4]([CH3:22])[N:5]([S:13]([C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)(=[O:15])=[O:14])[C:6]=1[C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1

参加物

反応物 3

HCID 4311764Sodium borohydride

HCID 57454252Monomethylamine methanol

HCID 86620751HCID 86620751、化合物

生成物 1

HCID 66924845HCID 66924845、化合物収率 84.9%

実験手順

Using 4-chloro-2-methyl-5-phenyl-1-(phenylsulfonyl)-1H-pyrrole-3-carbaldehyde (301 mg), 40% methylamine methanol solution (195 mg) and sodium borohydride (106 mg), a procedure as in Example 9 was performed. Recrystallization from a mixed solvent of ethyl acetate and ethanol gave the title compound as colorless crystals (yield 146 mg, 42%).

後処理

customRecrystallization from a mixed solvent of ethyl acetate and ethanol

出典と根拠

ORDレコード: ord-7ea855457f63469fb3c9e99bd984bc32
出典データセット: uspto-grants-2011_11
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US08048909B2

反応ノート

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