1-Chloro-4-isocyanato-2-(trifluoromethyl) benzene → 1-[4-(8-Nitroquinolin-4-yloxy)phenyl]-3-(4-chloro-3-trifluoromethylphenyl)urea

HRID 554481ノート

反応式

HRID 554481 の反応式
[N+:1]([C:4]1[CH:5]=[CH:6][CH:7]=[C:8]2[C:13]=1[N:12]=[CH:11][CH:10]=[C:9]2[O:14][C:15]1[CH:20]=[CH:19][C:18]([NH2:21])=[CH:17][CH:16]=1)([O-:3])=[O:2].[Cl:22][C:23]1[CH:28]=[CH:27][C:26]([N:29]=[C:30]=[O:31])=[CH:25][C:24]=1[C:32]([F:35])([F:34])[F:33]>O1CCCC1>[N+:1]([C:4]1[CH:5]=[CH:6][CH:7]=[C:8]2[C:13]=1[N:12]=[CH:11][CH:10]=[C:9]2[O:14][C:15]1[CH:20]=[CH:19][C:18]([NH:21][C:30]([NH:29][C:26]2[CH:27]=[CH:28][C:23]([Cl:22])=[C:24]([C:32]([F:34])([F:33])[F:35])[CH:25]=2)=[O:31])=[CH:17][CH:16]=1)([O-:3])=[O:2]

参加物

4

反応物 2

HCID 27332651-Chloro-4-isocyanato-2-(trifluoromethyl) benzeneHCID 533302934-(8-Nitroquinolin-4-yloxy)phenylamine

生成物 1

HCID 595094071-[4-(8-Nitroquinolin-4-yloxy)phenyl]-3-(4-chloro-3-trifluoromethylphenyl)urea収率 88.9%

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

4-(8-Nitroquinolin-4-yloxy)phenylamine (7.5 mg, 0.027 mmol) and 4-chloro-3-(trifluoromethyl)phenyl isocyanate (11.8 mg, 0.054 mmol) were dissolved in tetrahydrofuran, and stirred at room temperature for 12 hours. When the reaction was completed, the solvent was removed by vacuum distillation, and a white solid product was filtered to obtain 12.0 mg of the desired compound (yield 88.9%).

後処理

  1. customthe solvent was removed by vacuum distillation
  2. filtrationa white solid product was filtered

出典と根拠

ORDレコード
ord-b00dce08f2a34107933f7e0c12cf30b4
出典データセット
uspto-grants-2011_11
特許番号
US08049014B2

反応ノート

読み込み中…