Methyl 4-(2-benzyloxybenzyl)benzoate → Methyl 4-(2-hydroxybenzyl)benzoate

HRID 554533ノート

反応式

HRID 554533 の反応式
[CH3:1][O:2][C:3](=[O:25])[C:4]1[CH:9]=[CH:8][C:7]([CH2:10][C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=2[O:17]CC2C=CC=CC=2)=[CH:6][CH:5]=1>CO.[OH-].[Pd+2].[OH-]>[CH3:1][O:2][C:3](=[O:25])[C:4]1[CH:5]=[CH:6][C:7]([CH2:10][C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=2[OH:17])=[CH:8][CH:9]=1

参加物

4

反応物 1

HCID 21909320Methyl 4-(2-benzyloxybenzyl)benzoate

生成物 1

HCID 21909287Methyl 4-(2-hydroxybenzyl)benzoate収率 96%

試薬・触媒・溶媒 2

HCID 9942167Palladium hydroxide触媒HCID 887Methanol溶媒

実験手順

To a solution of 4-(2-benzyloxybenzyl)benzoic acid methyl ester (2.39 g, 7.19 mmol) in methanol (70 mL), a 20% palladium hydroxide catalyst (239 mg) was added. The mixture was stirred under a hydrogen atmosphere for five hours, and then the catalyst was filtered off. The solvent was distilled under reduced pressure to obtain the title compound (1.16 g, 96%).

後処理

  1. filtrationthe catalyst was filtered off
  2. distillationThe solvent was distilled under reduced pressure

出典と根拠

ORDレコード
ord-6b2966af80074a14aeeabd30cdb7dd1d
出典データセット
uspto-grants-2011_11
特許番号
US08048897B2

反応ノート

読み込み中…