Aluminium lithium hydride → 2-(2,3-dihydro-1H-indol-1-yl)ethan-1-ol

HRID 55475ノート

反応式

HRID 55475 の反応式
[N:1]1([CH2:10][C:11](OC)=[O:12])[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH2:3][CH2:2]1.[H-].[Al+3].[Li+].[H-].[H-].[H-]>O1CCCC1>[N:1]1([CH2:10][CH2:11][OH:12])[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH2:3][CH2:2]1

参加物

4

反応物 2

HCID 21226445Aluminium lithium hydrideHCID 22199910Methyl (2,3-dihydro-1H-indol-1-yl)acetate

生成物 1

HCID 232983052-(2,3-dihydro-1H-indol-1-yl)ethan-1-ol収率 87.1%

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

A procedure similar to that described in Preparation 2 was repeated, except that 780 mg of methyl indolin1-ylacetate (prepared as described in Preparation 8), 200 mg of lithium aluminum hydride and 12 ml of anhydrous tetrahydrofuran were used, to give 580 mg of the title compound having Rf=0.31 (on silica gel thin layer chromatography using a 2:1 by volume mixture of hexane and ethyl acetate as the developing solvent).

後処理

  1. customA procedure similar to that described in Preparation 2

出典と根拠

ORDレコード
ord-22a51bca3b2f4b4fbce4d57f55cb9f4b
出典データセット
uspto-grants-1997_04
特許番号
US05624935

反応ノート

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