Trimethylsilyldiazomethane → 6-Chloro-2-(3-methyl-3,4-dihydro-2H-pyrazol-3-vi)-3H-quinazolin-4-one

HRID 555259ノート

反応式

HRID 555259 の反応式
[Cl:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]=[C:7]([C:12]([CH3:14])=[CH2:13])[NH:6][C:5]2=[O:15].[Si]([CH:20]=[N+:21]=[N-:22])(C)(C)C>C1COCC1>[Cl:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]=[C:7]([C:12]1([CH3:14])[CH2:13][CH:20]=[N:21][NH:22]1)[NH:6][C:5]2=[O:15]

参加物

4

反応物 2

HCID 167693TrimethylsilyldiazomethaneHCID 1358145016-Chloro-2-isopropenyl-3H-quinazolin-4-one

生成物 1

HCID 1358145086-Chloro-2-(3-methyl-3,4-dihydro-2H-pyrazol-3-vi)-3H-quinazolin-4-one

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

6-Chloro-2-isopropenyl-3H-quinazolin-4-one (1 mmoL) in THF (5 mL) was treated with TMSCHN2 (1.0 N, 3.0 mmoL) at 50° C. for 4 h. The solvent was removed and the residue was purified by silica gel column chromatography to yield the title compound as a white solid.

後処理

  1. customThe solvent was removed
  2. customthe residue was purified by silica gel column chromatography

出典と根拠

ORDレコード
ord-67f79bc1ed954cf3a6db1f118fdec4d6
出典データセット
uspto-grants-2011_11
特許番号
US08053441B2

反応ノート

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