3-nitro-N-phenylpyridin-2-amine → 2-N-phenylpyridine-2,3-diamine

HRID 55526ノート

反応式

HRID 55526 の反応式
[N+:1]([C:4]1[C:5]([NH:10][C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)=[N:6][CH:7]=[CH:8][CH:9]=1)([O-])=O>C(O)C.O1CCOCC1.[Pd]>[NH2:1][C:4]1[C:5]([NH:10][C:11]2[CH:12]=[CH:13][CH:14]=[CH:15][CH:16]=2)=[N:6][CH:7]=[CH:8][CH:9]=1

参加物

5

反応物 1

HCID 6117993-nitro-N-phenylpyridin-2-amine

生成物 1

HCID 106790912-N-phenylpyridine-2,3-diamine収率 70.7%

試薬・触媒・溶媒 3

HCID 23938Palladium触媒HCID 702Ethanol溶媒HCID 312751,4-Dioxane溶媒

実験手順

A procedure similar to that described in Example 6 was repeated, except that 6.9 g of 3-nitro-2-phenylaminopyridine (prepared as described in Preparation 83) was hydrogenated in a mixture of 150 ml of ethanol and 50 ml of dioxane in the presence of 1.38 g of 10% w/w palladium-on-charcoal. After working up the product as described in Example 6, 4.2 g of the title compound, melting at 137°-140° C., were obtained.

出典と根拠

ORDレコード
ord-cde5596a9e9c4d7bb305df229f6d5b99
出典データセット
uspto-grants-1997_04
特許番号
US05624935

反応ノート

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