Methyl 4-[(2-hydroxyethyl)amino]-3-nitrobenzoate → HCID 51358181、化合物

HRID 555272ノート

反応式

HRID 555272 の反応式
[CH3:1][O:2][C:3](=[O:17])[C:4]1[CH:9]=[CH:8][C:7]([NH:10][CH2:11][CH2:12][OH:13])=[C:6]([N+:14]([O-])=O)[CH:5]=1>CO.[Pd]>[CH3:1][O:2][C:3](=[O:17])[C:4]1[CH:9]=[CH:8][C:7]([NH:10][CH2:11][CH2:12][OH:13])=[C:6]([NH2:14])[CH:5]=1

参加物

4

反応物 1

HCID 12257330Methyl 4-[(2-hydroxyethyl)amino]-3-nitrobenzoate

生成物 1

HCID 51358181HCID 51358181、化合物収率 99.7%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 887Methanol溶媒

実験手順

To a solution of 4-(2-hydroxy-ethylamino)-3-nitro-benzoic acid methyl ester (3.0 g, 12.4 mmol) in methanol was added 10% Pd/C (800 mg). The mixture was hydrogenated at 1 atmospheric pressure for 2 h. The catalyst was filtered off and the methanol evaporated to give 2.6 g (99%) of 3-amino-4-(2-hydroxyethylamino)-benzoic acid methyl ester.

後処理

  1. filtrationThe catalyst was filtered off
  2. customthe methanol evaporated

出典と根拠

ORDレコード
ord-63cf553c7328438fb1c66713f99db463
出典データセット
uspto-grants-2011_11
特許番号
US08053431B2

反応ノート

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