4-(2-Chloroethylamino)-3-nitro-benzoic Acid Methyl Ester → 3-Amino-4-(2-chloroethylamino)-benzoic acid methyl ester
反応式
[CH3:1][O:2][C:3](=[O:17])[C:4]1[CH:9]=[CH:8][C:7]([NH:10][CH2:11][CH2:12][Cl:13])=[C:6]([N+:14]([O-])=O)[CH:5]=1>CO.[Pd]>[CH3:1][O:2][C:3](=[O:17])[C:4]1[CH:9]=[CH:8][C:7]([NH:10][CH2:11][CH2:12][Cl:13])=[C:6]([NH2:14])[CH:5]=1参加物
4
実験手順
To a solution of 4-(2-chloroethylamino)-3-nitro-benzoic acid methyl ester (12.7 g, 0.0492 mol) in methanol (500 mL) was added 10% Pd/C (1.3 g) under a N2 atmosphere. The reaction mixture was hydrogenated in a Parr apparatus at 3 kg pressure for 2 h. The catalyst was filtered over celite and the filtrate was concentrated affording 11.0 g (98%) of 3-amino-4-(2-chloroethylamino)-benzoic acid methyl ester as a solid.
後処理
- filtrationThe catalyst was filtered over celite
- concentrationthe filtrate was concentrated
出典と根拠
- ORDレコード
- ord-85169878522e47488972aec505890d7b
- 出典データセット
- uspto-grants-2011_11
- 特許番号
- US08053431B2
反応ノート
読み込み中…