Hydrochloric Acid → HCID 45117461、化合物

HRID 555324ノート

反応式

HRID 555324 の反応式
C(OC([NH:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][N:15]1[C:24]2[C:19](=[CH:20][CH:21]=[CH:22][CH:23]=2)[CH:18]=[CH:17][C:16]1=[O:25])=O)(C)(C)C.Cl.[OH-].[Na+]>C(OCC)C.O>[NH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][N:15]1[C:24]2[C:19](=[CH:20][CH:21]=[CH:22][CH:23]=2)[CH:18]=[CH:17][C:16]1=[O:25]

参加物

6

反応物 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 66987879HCID 66987879、化合物

生成物 1

HCID 45117461HCID 45117461、化合物

試薬・触媒・溶媒 2

HCID 962Water溶媒HCID 3283Diethyl Ether溶媒

実験手順

1-[6-(N-tert-Butoxycarbonylamino)-1-hexyl]-1,2-dihydroquinoline-2-one (480 mg) was treated with a large excess of hydrogen chloride in dietyl ether with stirring for 1 hour at room temperature. The crystalline product was isolated by filtration and redissolved in water whereafter the solution was made strongly alkaline with sodium hydroxide and extracted twice with chloroform. The organic phase was dried over potassium carbonate, filtered and evaporated to yield the title compound as a colourless oil.

後処理

  1. customThe crystalline product was isolated by filtration
  2. extractionextracted twice with chloroform
  3. dry with materialThe organic phase was dried over potassium carbonate
  4. filtrationfiltered
  5. customevaporated

出典と根拠

ORDレコード
ord-cf6bfbedb1b941a1a6c920199ba03243
出典データセット
uspto-grants-2011_11
特許番号
US08053446B2

反応ノート

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