2,3-Bis(mercaptoisobutryl) propionic acid → 2,3-Bis(mercaptoisobutryl)propanol

HRID 55556ノート

反応式

HRID 55556 の反応式
[SH:1][C:2]([CH3:17])([CH3:16])[C:3]([CH:5]([CH2:9][C:10](=[O:15])[C:11]([SH:14])([CH3:13])[CH3:12])[C:6](O)=[O:7])=[O:4]>O1CCCC1>[SH:1][C:2]([CH3:17])([CH3:16])[C:3]([CH:5]([CH2:9][C:10](=[O:15])[C:11]([SH:14])([CH3:13])[CH3:12])[CH2:6][OH:7])=[O:4]

参加物

3

反応物 1

HCID 867445382,3-Bis(mercaptoisobutryl) propionic acid

生成物 1

HCID 867445372,3-Bis(mercaptoisobutryl)propanol

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒2 回

実験手順

To an ice-cold solution of 2,3-bis(mercaptoisobutryl) propionic acid 9 (Scheme 1) (1 mmol) in 10 mL of anhydrous tetrahydrofuran, 1.5 mL of 1M BH3. THF is added over a period of 5 minutes (min.). The solution is stirred for another 10 min. and evaporated to dryness. Ten ml of water is added to the residue and the mixture is extracted with ethyl acetate. The organic layer is washed with water, dried and evaporated in vacuo to give the product 21, which is purified by flash column chromatography.

後処理

  1. customevaporated to dryness
  2. additionTen ml of water is added to the residue
  3. extractionthe mixture is extracted with ethyl acetate
  4. washThe organic layer is washed with water
  5. customdried
  6. customevaporated in vacuo

出典と根拠

ORDレコード
ord-2000ec8f9485405eb882661a07973a55
出典データセット
uspto-grants-1997_04
特許番号
US05625075

反応ノート

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