Hydrochloric Acid → HCID 178433891、化合物

反応式

[C:1]([C:5]1[CH:10]=[CH:9][C:8]([N:11]2[C:15](=[O:16])[C:14](=[CH:17][NH:18][NH:19][C:20](=[O:31])[C:21]3[CH:26]=[CH:25][C:24]([C:27]([O:29]C)=[O:28])=[CH:23][CH:22]=3)[C:13]([CH3:32])=[N:12]2)=[CH:7][CH:6]=1)([CH3:4])([CH3:3])[CH3:2].[OH-].[Na+].Cl>CO>[C:1]([C:5]1[CH:6]=[CH:7][C:8]([N:11]2[C:15](=[O:16])[C:14](=[CH:17][NH:18][NH:19][C:20](=[O:31])[C:21]3[CH:22]=[CH:23][C:24]([C:27]([OH:29])=[O:28])=[CH:25][CH:26]=3)[C:13]([CH3:32])=[N:12]2)=[CH:9][CH:10]=1)([CH3:4])([CH3:2])[CH3:3]

参加物

実験手順

59.4 mg (0.14 mmol) of the 4-methoxycarbonylbenzoic N′-(1-(4-tert-butylphenyl)-3-methyl-5-oxo-1,5-dihydropyrazol-4-ylidene-methyl)-hydrazide synthesized in 2) was dissolved in 5.0 ml of methanol and stirred with 0.68 ml (0.68 mmol) of 1M aqueous sodium hydroxide at room temperature for 6 hours and then at 60° C. for 3 hours. After the stirring, 0.68 ml (0.68 mmol) of hydrochloric acid was added, and the precipitated solid was collected by filtration and dried to obtain 33.3 mg of the above-identified desired product as a yellow solid (yield 58%).