Piperidine → HCID 66986626、化合物

HRID 555665

反応式

HRID 555665 の反応式
[C:1]([N:4]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[CH2:6][C:5]1=[O:13])(=[O:3])[CH3:2].O[CH2:15][C:16]1[O:20][C:19]([CH:21]=[O:22])=[CH:18][CH:17]=1.N1CCCCC1>C(O)C>[OH:22][CH2:21][C:19]1[O:20][C:16]([CH:15]=[C:6]2[C:7]3[C:12](=[CH:11][CH:10]=[CH:9][CH:8]=3)[N:4]([C:1](=[O:3])[CH3:2])[C:5]2=[O:13])=[CH:17][CH:18]=1

参加物

5

反応物 3

HCID 8082PiperidineHCID 2373325-(Hydroxymethyl)furfuralHCID 3237191-Acetylindolin-2-one

生成物 1

HCID 66986626HCID 66986626、化合物

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒2 回

実験手順

N-acetyloxindole (1 equivalent), 5-hydroxymethyl-2-furaldehyde (0.5 equivalent) and piperidine (0.2 equivalent) were dissolved in ethanol such that 1 mL of ethanol was used per 1 μmol of the total amount of the compounds, and the resulting mixture was stirred at room temperature for 12 hours. After completion of the reaction, the resulting precipitate was collected by filtration, washed with cooled ethanol several times and dried, whereby 3-((5-(hydroxymethyl)furan-2-yl) methylene)-N-acetyl-2-oxoindoline was obtained.

後処理

  1. customAfter completion of the reaction
  2. filtrationthe resulting precipitate was collected by filtration
  3. washwashed with cooled ethanol several times
  4. customdried

出典と根拠

ORDレコード
ord-d681d2db206c4d6eadb06b44412df9dd
出典データセット
uspto-grants-2011_11
特許番号
US08053461B2

関連ノート

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