(2S)-2-amino-2-(4-chlorophenyl)acetic acid → (S)-2-Amino-2-(4-chlorophenyl)ethanol
反応式
[CH:1]1[C:6]([C@H:7]([NH2:11])[C:8](O)=[O:9])=[CH:5][CH:4]=[C:3]([Cl:12])[CH:2]=1.[H-].[H-].[H-].[H-].[Li+].[Al+3]>C1COCC1>[NH2:11][C@@H:7]([C:6]1[CH:5]=[CH:4][C:3]([Cl:12])=[CH:2][CH:1]=1)[CH2:8][OH:9]参加物
4
実験手順
A mixture of L-4-chloro-phenylglycine (1.74 g, 9.37 mmol) and LAH (712 mg, 18.75 mmol) in THF (40 mL) is refluxed for 1.5 h. After completion, the reaction mixture is quenched by Na2SO4.10H2O and the product is isolated by filtration with Celite, washed with THF and dried under reduced pressure to give the title compound as oil; HPLC: AtRet=1.46 min; 1HNMR (DMSO-d6) 7.35 (d, 2H), 7.30 (d, 2H), 4.80 (bs, 1H), 3.85-3.80 (m, 1H), 3.45-3.20 (m, 2H), 1.85 (bs, 2H).
後処理
- temperatureis refluxed for 1.5 h
- customAfter completion, the reaction mixture is quenched by Na2SO4.10H2O
- customthe product is isolated by filtration with Celite
- washwashed with THF
- customdried under reduced pressure
出典と根拠
- ORDレコード
- ord-906babafbc5a44abb927d546ccb97ef5
- 出典データセット
- uspto-grants-2011_11
- 特許番号
- US08053457B2
反応ノート
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