Bromoacetonitrile → (4-Ethylpiperazin-1-yl)acetonitrile

反応式

[CH2:1]([N:3]1[CH2:8][CH2:7][NH:6][CH2:5][CH2:4]1)[CH3:2].Br[CH2:10][C:11]#[N:12]>>[CH2:1]([N:3]1[CH2:8][CH2:7][N:6]([CH2:10][C:11]#[N:12])[CH2:5][CH2:4]1)[CH3:2]

参加物

反応物 2

HCID 11534Bromoacetonitrile

HCID 791961-Ethylpiperazine

生成物 1

HCID 22688890(4-Ethylpiperazin-1-yl)acetonitrile

実験手順

The title compound is synthesized by coupling of 1-Ethyl-piperazine and bromoacetonitrile analogously to the preparation of Intermediate 149.2 as a orange oil; ES-MS: M+=154.1: 1HNMR(DMSO-d6) 3.70 (s, 2H), 2.40-2.20 (m, 10H), 0.95 (t, 3H).

出典と根拠

ORDレコード: ord-afeccc5d3e064fe89e881a26b52a4572
出典データセット: uspto-grants-2011_11
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US08053457B2

反応ノート

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