Bromoacetonitrile → [4-(2-Pyrrolidin-1-yl-ethyl)-piperazin-1-yl]-acetonitrile

反応式

[N:1]1([CH2:6][CH2:7][N:8]2[CH2:13][CH2:12][NH:11][CH2:10][CH2:9]2)[CH2:5][CH2:4][CH2:3][CH2:2]1.Br[CH2:15][C:16]#[N:17]>>[N:1]1([CH2:6][CH2:7][N:8]2[CH2:9][CH2:10][N:11]([CH2:15][C:16]#[N:17])[CH2:12][CH2:13]2)[CH2:2][CH2:3][CH2:4][CH2:5]1

参加物

反応物 2

HCID 11534Bromoacetonitrile

HCID 27372501-[2-(Pyrrolidin-1-yl)ethyl]piperazine

生成物 1

HCID 86641786[4-(2-Pyrrolidin-1-yl-ethyl)-piperazin-1-yl]-acetonitrile

実験手順

The title compound is synthesized by coupling of 1-(2-Pyrrolidin-1-yl-ethyl)-piperazine (commercially available from ABCR GmbH) and bromoacetonitrile analogously to the preparation of Intermediate 149.2 as a colorless solid; ES-MS: M+H=223.3.

後処理

customanalogously to the preparation of Intermediate 149.2 as a colorless solid

出典と根拠

ORDレコード: ord-aa9b629df78b41f2b1ce2a53e27f35f5
出典データセット: uspto-grants-2011_11
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US08053457B2

反応ノート

読み込み中…