Bromoacetonitrile → [4-(3-Methoxy-propyl)-piperazin-1-yl]acetonitrile

HRID 555735

反応式

HRID 555735 の反応式
[CH3:1][O:2][CH2:3][CH2:4][CH2:5][N:6]1[CH2:11][CH2:10][NH:9][CH2:8][CH2:7]1.Br[CH2:13][C:14]#[N:15]>>[CH3:1][O:2][CH2:3][CH2:4][CH2:5][N:6]1[CH2:7][CH2:8][N:9]([CH2:13][C:14]#[N:15])[CH2:10][CH2:11]1

参加物

3

反応物 2

HCID 11534BromoacetonitrileHCID 18225361-(3-Methoxypropyl)piperazine

生成物 1

HCID 63337188[4-(3-Methoxy-propyl)-piperazin-1-yl]acetonitrile

実験手順

The title compound is synthesized by coupling of 1-(3-Methoxy-propyl)-piperazine (commercially available from CHESS GmbH) and bromoacetonitrile analogously to the preparation of Intermediate 149.2 as a colorless oil; ES-MS: M+=198.2: 1HNMR(DMSO-d6) 3.65 (s, 2H), 3.30 (s, 3H), 2.45-2.20 (m, 12H), 1.65-1.55 (m, 2H).

後処理

  1. customanalogously to the preparation of Intermediate 149.2 as a colorless oil

出典と根拠

ORDレコード
ord-5a961d53f151413babf4cc3829fa4668
出典データセット
uspto-grants-2011_11
特許番号
US08053457B2

関連ノート

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