Bromoacetonitrile → HCID 86641791、化合物

反応式

[CH2:1]([N:4]([CH2:11][CH2:12][CH3:13])[CH:5]1[CH2:10][CH2:9][NH:8][CH2:7][CH2:6]1)[CH2:2][CH3:3].Br[CH2:15][C:16]#[N:17]>>[CH2:11]([N:4]([CH2:1][CH2:2][CH3:3])[CH:5]1[CH2:6][CH2:7][N:8]([CH2:15][C:16]#[N:17])[CH2:9][CH2:10]1)[CH2:12][CH3:13]

参加物

反応物 2

HCID 11534Bromoacetonitrile

HCID 3824021N,N-dipropylpiperidin-4-amine

生成物 1

HCID 86641791HCID 86641791、化合物

実験手順

The title compound is synthesized by coupling of Dipropyl-piperidin-4-yl-amine (commercially available from CHESS GmbH) and bromoacetonitrile analogously to the preparation of Intermediate 149.2 as a colorless oil; ES-MS: M+=224.3: 1HNMR(DMSO-d6) 3.65 (s, 2H), 2.80-2.75 (m, 2H), 2.40-2.30 (m, 5H), 2.15-2.05 (m, 2H), 1.65-1.60 (m, 2H), 1.50-1.30 (m, 6H), 0.90 (t, 6H).

後処理

customanalogously to the preparation of Intermediate 149.2 as a colorless oil

出典と根拠

ORDレコード: ord-4e75c051083d4c29acc07f67bbbc1262
出典データセット: uspto-grants-2011_11
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US08053457B2

反応ノート

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