Bromoacetonitrile → (4-Indan-1-yl-piperazin-1-yl)-acetonitrile
反応式
[CH:1]1([N:10]2[CH2:15][CH2:14][NH:13][CH2:12][CH2:11]2)[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH2:3][CH2:2]1.Br[CH2:17][C:18]#[N:19]>>[CH:1]1([N:10]2[CH2:15][CH2:14][N:13]([CH2:17][C:18]#[N:19])[CH2:12][CH2:11]2)[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH2:3][CH2:2]1参加物
3
実験手順
The title compound is synthesized by coupling of 1-Indan-1-yl-piperazine (commercially available from CHESS GmbH) and bromoacetonitrile analogously to the preparation of Intermediate 149.2 as a colorless oil; ES-MS: M+H=242.2: CtRet=4.25.
後処理
- customanalogously to the preparation of Intermediate 149.2 as a colorless oil
出典と根拠
- ORDレコード
- ord-4e927e96c23c49c6ae3fdb6766f989c0
- 出典データセット
- uspto-grants-2011_11
- 特許番号
- US08053457B2
反応ノート
読み込み中…