1,1'-Carbonyldiimidazole → n-(6-Bromo-1,3-benzothiazol-2-yl)-1h-imidazole-1-carboxamide
反応式
[Br:1][C:2]1[CH:11]=[CH:10][C:5]2[N:6]=[C:7]([NH2:9])[S:8][C:4]=2[CH:3]=1.[CH:12]1[N:16]=[CH:15][N:14]([C:17](N2C=NC=C2)=[O:18])[CH:13]=1>C(Cl)Cl>[Br:1][C:2]1[CH:11]=[CH:10][C:5]2[N:6]=[C:7]([NH:9][C:17]([N:14]3[CH:13]=[CH:12][N:16]=[CH:15]3)=[O:18])[S:8][C:4]=2[CH:3]=1参加物
4
実験手順
A suspension of 6-bromo-benzothiazol-2-ylamine (5 g, 21.83 mmol) in DCM (250 ml) is treated with CDI (3.54 g, 21.83 mmol) and the reaction mixture is heated to reflux for 2 hours. The reaction mixture is filtered and the resulting solid is dried in the vacuum oven overnight to afford the title compound.
後処理
- temperaturethe reaction mixture is heated
- temperatureto reflux for 2 hours
- filtrationThe reaction mixture is filtered
- customthe resulting solid is dried in the vacuum oven overnight
出典と根拠
- ORDレコード
- ord-f27298b6cd944f8994516c973546a063
- 出典データセット
- uspto-grants-2011_11
- 特許番号
- US08053574B2
反応ノート
読み込み中…