Pyridine → 1,8-Bis[2-(Isobutylamino)Acetamido]Anthraquinone

HRID 556199

反応式

HRID 556199 の反応式
Cl[CH2:2][C:3]([NH:5][C:6]1[C:19]2[C:18](=[O:20])[C:17]3[C:12](=[CH:13][CH:14]=[CH:15][C:16]=3[NH:21][C:22](=[O:25])[CH2:23]Cl)[C:11](=[O:26])[C:10]=2[CH:9]=[CH:8][CH:7]=1)=[O:4].[N:27]1[CH:32]=[CH:31][CH:30]=CC=1.[CH2:33]([NH2:37])[CH:34]([CH3:36])[CH3:35].[CH3:38]N(C)C=O>>[CH2:33]([NH:37][CH2:2][C:3]([NH:5][C:6]1[C:19]2[C:18](=[O:20])[C:17]3[C:12](=[CH:13][CH:14]=[CH:15][C:16]=3[NH:21][C:22](=[O:25])[CH2:23][NH:27][CH2:32][CH:31]([CH3:30])[CH3:38])[C:11](=[O:26])[C:10]=2[CH:9]=[CH:8][CH:7]=1)=[O:4])[CH:34]([CH3:36])[CH3:35]

参加物

5

反応物 4

HCID 1049PyridineHCID 6228DimethylformamideHCID 6558IsobutylamineHCID 469280411,8-Bis(chloroacetamido)anthraquinone2 回

生成物 1

HCID 462447741,8-Bis[2-(Isobutylamino)Acetamido]Anthraquinone収率 40%

実験手順

Add 0.4 g, 1.0 mmol 1,8-bis(chloroacetamido)anthraquinone (compound 3) with pyridine (0.5 ml), and 0.6 ml, 6 mmole Isobutylamine, dissolved in 20 ml dehydrated dimethylformamide (DMF). The mixture is reacted in a mini-reactor. The reaction temperature is 120° C. in the oil bath and the reaction time is 30 minutes. The reacted mixture is poured into 50 ml ice water and is filtered to collect precipitate. The precipitate is recrystallized from ethanol to get yellow compound 3k.

後処理

  1. customThe mixture is reacted in a mini-reactor
  2. customis 120° C. in the oil bath
  3. filtrationis filtered
  4. customto collect precipitate
  5. customThe precipitate is recrystallized from ethanol

出典と根拠

ORDレコード
ord-00e4a8deecdb438ead2a29856169bd86
出典データセット
uspto-grants-2011_11
特許番号
US08053583B2

関連ノート

読み込み中…