Pyridine → 1,8-Bis[2-(diethylamino)acetamido]anthraquinone

HRID 556200

反応式

HRID 556200 の反応式
Cl[CH2:2][C:3]([NH:5][C:6]1[C:19]2[C:18](=[O:20])[C:17]3[C:12](=[CH:13][CH:14]=[CH:15][C:16]=3[NH:21][C:22](=[O:25])[CH2:23]Cl)[C:11](=[O:26])[C:10]=2[CH:9]=[CH:8][CH:7]=1)=[O:4].[N:27]1[CH:32]=[CH:31]C=[CH:29][CH:28]=1.[CH2:33]([NH:35][CH2:36][CH3:37])[CH3:34]>CN(C)C=O>[CH2:32]([N:27]([CH2:28][CH3:29])[CH2:2][C:3]([NH:5][C:6]1[C:19]2[C:18](=[O:20])[C:17]3[C:12](=[CH:13][CH:14]=[CH:15][C:16]=3[NH:21][C:22](=[O:25])[CH2:23][N:35]([CH2:36][CH3:37])[CH2:33][CH3:34])[C:11](=[O:26])[C:10]=2[CH:9]=[CH:8][CH:7]=1)=[O:4])[CH3:31]

参加物

5

反応物 3

HCID 1049PyridineHCID 8021DiethylamineHCID 469280411,8-Bis(chloroacetamido)anthraquinone2 回

生成物 1

HCID 462447751,8-Bis[2-(diethylamino)acetamido]anthraquinone収率 70%

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

Add 0.4 g, 1.0 mmol 1,8-bis(chloroacetamido)anthraquinone (compound 3) with pyridine (0.5 ml), and 0.6 ml, 6 mmole Diethylamine, dissolved in 20 ml dehydrated dimethylformamide (DMF). The mixture is reacted in a mini-reactor. The reaction temperature is 120° C. in the oil bath and the reaction time is 30 minutes. The reacted mixture is poured into 50 ml ice water and is filtered to collect precipitate. The precipitate is recrystallized from ethanol to get yellow compound 3l.

後処理

  1. customThe mixture is reacted in a mini-reactor
  2. customis 120° C. in the oil bath
  3. filtrationis filtered
  4. customto collect precipitate
  5. customThe precipitate is recrystallized from ethanol

出典と根拠

ORDレコード
ord-7fa87425d52c47a5b3831c9a71c45e7e
出典データセット
uspto-grants-2011_11
特許番号
US08053583B2

関連ノート

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